[Several mechanisms appear to be involved in the escape of melanoma from immunologic control, 1) downregulation of surface-expressed major histocompatibility complex class I molecules and the failure of tumor cells to process endogenously synthesized proteins for antigen presentation, 2) inhibition of the interaction of cytotoxic T cells with melanoma cells, eg, by soluble adhesion molecules (intercellular adhesion molecule 1), and 3) induction and maintenance of clonal anergy in tumor cell-specific T cells.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
Gene-disease associations inferred from text-mining the literature.
DisGeNET evidence - LITERATURE