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http://purl.bioontology.org/ontology/MSH/D017209
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a(CHEBI:paclitaxel) -> bp(MESHPP:Apoptosis)
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a(SCHEM:"LY 294002") -> (a(CHEBI:paclitaxel) -> bp(MESHPP:Apoptosis))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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As shown in Figure 5B, combining LY294002 with paclitaxel increased apoptosis above that observed with paclitaxel alone, consistent with prior studies from our laboratory (11). Although nicotine protected the cells from paclitaxel alone, the protective effect of nicotine was lost in the presence of LY294002, suggesting that the anti-apoptotic effects of nicotine are dependent upon the activation of the PI3K/Akt pathway.
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Selventa
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2014-07-03T14:32:42.029+02:00
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