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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#_5 http://www.w3.org/ns/prov#value Transient transfections and electrophoretic-mobility-shift assays suggested that PHOX2B is able to bind the cell-specific element in the 5' regulatory region of the TLX2 gene, determining its transactivation in neuroblastoma cells. Such interaction was also confirmed in vivo by means of chromatin immunoprecipitation assay and, in addition, up-regulation of endogenous TLX2 mRNA level was demonstrated following PHOX2B over-expression, by quantitative real-time PCR. http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16402914 http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16402914 http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#_5 http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI http://purl.org/dc/terms/created 2014-07-03T14:32:54.819+02:00 http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAim0bxiXnIhoWdw7FK574tl6qqkNI7GiPu2CAmqWRMCI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234