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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#_5 http://www.w3.org/ns/prov#value As shown in Fig. 3A, activins AB and B augmented (SBE)4-lux reporter activity in MIN6 cells. To verify that activin isoforms signal is mediated via ALK7 in MIN6 cells, we measured the activity of the dominant negative ALK7 construct (D/N ALK7 cDNA). D/N ALK7 cDNA lacks the intracellular kinase domain but retains the extracellular and transmembrane domains. The specificity of D/N ALK7 was confirmed in HEK293 cells (Fig. 3B). The activity of ALK4-dependent activin signaling was barely affected in the D/N ALK7 construct, but the ALK7-augmented response to activins B and AB was significantly inhibited. Thus, D/N ALK7 is a dominant negative inhibitor of ALK7 signaling but not of the ALK4 pathway ( Fig. 3B). As shown in Fig. 3C, D/N ALK7 completely blocked the responses of MIN6 cells to activins AB and B, confirming that activin isoforms signal via ALK7 in MIN6 cells http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15196700 http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15196700 http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#_5 http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8 http://purl.org/dc/terms/created 2014-07-03T14:32:22.482+02:00 http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiZ5D7DuuHDK1uqDhd5U1HYYYibsQ4CckUAUlP_LrdT8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234