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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#_5 http://www.w3.org/ns/prov#value We found that expression of Elf5 was induced by FGF7 and FGF10, ligands that primarily bind FGFR2b. To further define the pathways by which FGFs activate Elf5 expression, we cultured E11.5 lung tips in the presence of compounds to inhibit FGF receptors (SU5402), PI3-Kinase/Akt-mediated signaling (LY294002), and MAP Kinase/Erk-mediated signaling (U0126). We found that SU5402 and LY294002 significantly reduced Elf5 expression, whereas U0126 had no effect. LY294002 also reduced Elf5 expression in cultures of purified epithelium. Finally, pAkt was coexpressed with Elf5 in the proximal epithelial airways of E17.5 lungs. These results demonstrate that Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression and that FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway. http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17394208 http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17394208 http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#_5 http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc http://purl.org/dc/terms/created 2014-07-03T14:30:50.242+02:00 http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiSP_MavYGUkBzWOspy0aKn3C0a2Gw7SzgRlP0Z6RUJc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234