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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#_4 http://www.w3.org/ns/prov#value The presence of a consensus binding site (CGCCCCCGC) for the transcription factor Egr-1 (synonymous with Krox-24, NGFI-A, Zif268, and TIS-8) at bp -163 is particularly notable. This site has been shown to bind a family of zinc finger proteins that are immediate early response genes important in growth regulation. Egr-1 expression is rapidly and transiently induced by nerve growth factor in PC12 cells and by serum in fibroblasts. Of particular relevance is the observation that Egr-1 is induced during the G/G transition in the cell cycle after mitogenic stimulation of T lymphocytes, as well as during G as a separate event mediated by interleukin-2. http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7896827 http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7896827 http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#_4 http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg http://purl.org/dc/terms/created 2014-07-03T14:33:47.088+02:00 http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAiQCPR7UO_IkxzyZ4fUXbcIcJKnYiWJPHyxDPKmVR-hg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234