sub:provenance { beldoc:dce:description "Approximately 61,000 statements." ; dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ; dce:title "BEL Framework Large Corpus Document" ; pav:authoredBysub:_5 ; pav:version "20131211" . sub:_4prov:value "The presence of a consensus binding site (CGCCCCCGC) for the transcription factor Egr-1 (synonymous with Krox-24, NGFI-A, Zif268, and TIS-8) at bp -163 is particularly notable. This site has been shown to bind a family of zinc finger proteins that are immediate early response genes important in growth regulation. Egr-1 expression is rapidly and transiently induced by nerve growth factor in PC12 cells and by serum in fibroblasts. Of particular relevance is the observation that Egr-1 is induced during the G/G transition in the cell cycle after mitogenic stimulation of T lymphocytes, as well as during G as a separate event mediated by interleukin-2." ; prov:wasQuotedFrompubmed:7896827 . sub:_5rdfs:label "Selventa" . sub:assertionprov:hadPrimarySourcepubmed:7896827 ; prov:wasDerivedFrombeldoc: , sub:_4 . }