http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#Head http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#provenance http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1100 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.lgcstandards-atcc.org/Products/All/CRL-1573.aspx http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_1 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://amigo.geneontology.org/amigo/term/GO:0009411 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.w3.org/2000/01/rdf-schema#label bp(GO:"response to UV") -> r(HGNC:BRCA1) http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_3 http://www.w3.org/ns/prov#value We show here that the expression of E2F6 was downregulated with a concurrent increase in BRCA1 mRNA and cleaved protein during ultraviolet (UV)-induced apoptosis in human embryonic kidney 293 cells. Moreover, E2F6 overexpression distinctly inhibited UV-induced apoptosis as well as UV-induced increases in BRCA1 expression and cleavage, accompanied with increases of the full-length BRCA1 and BRCA1 nuclear foci. In contrast, knockdown of E2F6 by small interfering RNA had opposite effects. Furthermore, these effects of E2F6 on BRCA1 depended upon the association of E2F6 with BRCA1 via its C-terminus in a UV-triggered manner and upon the transcriptional repression by E2F6 on the BRCA1 promoter. http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#_3 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://purl.org/dc/terms/created 2014-07-03T14:30:48.274+02:00 http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAi0qc7D_e8-uGmIe0PLO5Xh_o-gEuqkB2LbiqUnwBOmo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234