http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#Head http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#provenance http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://disease-ontology.org/term/DOID:1936 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000235 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/UBERON_0001969 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://amigo.geneontology.org/amigo/term/GO:0007596 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=41526 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:"carbon monoxide") -| bp(GOBP:"blood coagulation") http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_2 http://www.w3.org/ns/prov#value It has been shown that exogenous CO (ca. 300 parts per million) reduces inflammatory responses in several models of oxidant injury, which is consistent with results observed with HO-1 overexpression (Abraham et al., 1995a; Amersi et al., 1999). Although CO acts in many ways that are similar to NO, CO possesses additional functions on signal transduction pathways. CO inhibits pro-inflammatory genes while augmenting antiinflammatory cytokine production by selective activation of several p38 mitogen-activated protein kinase (MAPK) signaling pathways in a guanylyl cyclase-independent manner (Brouard et al., 2000; Otterbein et al., 2000; Sarady et al., 2002; Song et al., 2003). Other important effects of CO involve inhibition of proliferation of vascular smooth muscle cells, inhibition of platelet aggregation, protection against apoptosis, and acting as a neurotransmitter (Brune and Ullrich, 1987; Durante and Schafer, 1998; Brouard et al., 2000; Togane et al., 2000; Baranano and Snyder, 2001). Therefore, although high amounts of CO are lethal, low concentrations of CO mediate many important physiological functions, such as maintenance of vasomotor tone and mediating neurotransmission (Johnson et al., 1999). http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12869663 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#_2 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw#pubinfo http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://purl.org/dc/terms/created 2014-07-03T14:32:04.838+02:00 http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAi0mUQ6AWHeGLWjaj2q59VODCmn3Ha-pwj5ISuz8EVuw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234