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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#_3 http://www.w3.org/ns/prov#value We show here that the expression of E2F6 was downregulated with a concurrent increase in BRCA1 mRNA and cleaved protein during ultraviolet (UV)-induced apoptosis in human embryonic kidney 293 cells. Moreover, E2F6 overexpression distinctly inhibited UV-induced apoptosis as well as UV-induced increases in BRCA1 expression and cleavage, accompanied with increases of the full-length BRCA1 and BRCA1 nuclear foci. In contrast, knockdown of E2F6 by small interfering RNA had opposite effects. Furthermore, these effects of E2F6 on BRCA1 depended upon the association of E2F6 with BRCA1 via its C-terminus in a UV-triggered manner and upon the transcriptional repression by E2F6 on the BRCA1 promoter. http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17096023 http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#_3 http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s http://purl.org/dc/terms/created 2014-07-03T14:33:06.690+02:00 http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAhuhEiwLB9R1ZjFmhDSUyIdx1xcbip94J5omDgOql59s http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234