@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAhiYmbUAABh5YRFuHt6ehtYgIzmQdHn6-1NqjjaAGkc8> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAhiYmbUAABh5YRFuHt6ehtYgIzmQdHn6-1NqjjaAGkc8#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 occursIn: obo:CL_0002328, species:9606;
    rdf:object go:0034984;
    rdf:predicate belv:increases;
    rdf:subject chebi:3343;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:camptothecin) -> bp(GOBP:\"cellular response to DNA damage stimulus\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_3;
    pav:version "20131211" .
  
  sub:_2 prov:value "To study the effect of cigarette smoke on DNA damage, bronchial epithelial cells were exposed to either 5% CSE or 1 µM CPT for 24 h. The quantitative in situ TUNEL assay, in parallel with the MTT assay, was performed after 1-, 2-, 4-, 6-, and 24-h exposure. As shown in Figure 1, even 1 h of exposure to 5% CSE or CPT caused a significant increase of TUNEL-positive cells (54.9 ± 3.0% by 5% CSE and 31.2 ± 2.2% by CPT, respectively, P < 0.05 compared with control of 16.2 ± 0.3%, Figure 1A). TUNEL-positive cells gradually increased to nearly 90% in both 5% CSE- and CPT-treated groups as a function of time, although the 5% CSE effect was stronger than 1 µM CPT during the first 4 h. Cell viability as assessed by MTT, however, was not affected by 5% CSE but was significantly reduced by CPT at 6 h (100.3 ± 3.3% versus 61.3 ± 5.5% of control, P < 0.05) and at 24 h (103.2 ± 7.6% versus 26.6 ± 1.9% of control, P < 0.05; Figure 1B). Cigarette smoke-induced DNA damage was dependent on CSE concentration. ";
    prov:wasQuotedFrom pubmed:15845867 .
  
  sub:_3 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15845867;
    prov:wasDerivedFrom beldoc:, sub:_2 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:43.644+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}