. . . . . . . . . . . . . . . . "p(MGI:Inhbb) -> kin(p(MGI:Acvr1c))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "As shown in Fig. 3A, activins AB and B augmented (SBE)4-lux reporter activity in MIN6 cells. To verify that activin isoforms signal is mediated via ALK7 in MIN6 cells, we measured the activity of the dominant negative ALK7 construct (D/N ALK7 cDNA). D/N ALK7 cDNA lacks the intracellular kinase domain but retains the extracellular and transmembrane domains. The specificity of D/N ALK7 was confirmed in HEK293 cells (Fig. 3B). The activity of ALK4-dependent activin signaling was barely affected in the D/N ALK7 construct, but the ALK7-augmented response to activins B and AB was significantly inhibited. Thus, D/N ALK7 is a dominant negative inhibitor of ALK7 signaling but not of the ALK4 pathway ( Fig. 3B). As shown in Fig. 3C, D/N ALK7 completely blocked the responses of MIN6 cells to activins AB and B, confirming that activin isoforms signal via ALK7 in MIN6 cells" . . "Selventa" . . . . "2014-07-03T14:32:22.484+02:00"^^ . . .