@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAhRPkC1Iy218gq9ZH9L5dVV5Kv88fSic9DlFxBLLahk0> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAhRPkC1Iy218gq9ZH9L5dVV5Kv88fSic9DlFxBLLahk0#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 rdf:object mesh:D017209 ;
    rdf:predicate belv:increases ;
    rdf:subject chebi:7887 ;
    a rdf:Statement .
  sub:_2 occursIn: obo:EFO_0003118 , obo:UBERON_0002048 , species:9606 ;
    rdf:object sub:_1 ;
    rdf:predicate belv:decreases ;
    rdf:subject chebi:18723 ;
    a rdf:Statement .
  sub:assertion rdfs:label "a(CHEBI:nicotine) -| (a(CHEBI:paclitaxel) -> bp(MESHPP:Apoptosis))" , "a(CHEBI:paclitaxel) -> bp(MESHPP:Apoptosis)" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_4 ;
    pav:version "20131211" .
  sub:_3 prov:value "As shown in Figure 5B, combining LY294002 with paclitaxel increased apoptosis above that observed with paclitaxel alone, consistent with prior studies from our laboratory (11). Although nicotine protected the cells from paclitaxel alone, the protective effect of nicotine was lost in the presence of LY294002, suggesting that the anti-apoptotic effects of nicotine are dependent upon the activation of the PI3K/Akt pathway." ;
    prov:wasQuotedFrom pubmed:15790591 .
  sub:_4 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:15790591 ;
    prov:wasDerivedFrom beldoc: , sub:_3 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:32:42.031+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}