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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#_4 http://www.w3.org/ns/prov#value Mitochondrial aldehyde dehydrogenase (ALDH2) activity is produced at low levels in many tissues, with highest production in liver. Transfection assays using the first 600 bp of upstream DNA provided evidence for both positive and negative regulatory elements in the proximal promoter. A region from -79 to -116 bp was protected in DNase I footprinting assays and bound in electrophoretic mobility shift assays (EMSA) by a nuclear factor found in all cell lines and tissues tested. This region, denoted FP160, contained the consensus recognition sites for Sp1 and AP2, and a CCAAT box. The CCAAT box was specifically protected by a nuclear factor in methylation interference assays. Mutagenesis of specific bp within the CCAAT box eliminated protein binding in vitro and decreased transcriptional activity from the ALDH2 promoter approximately 50% in reporter gene assays. Competition experiments showed that the nuclear factor binding to the FP160 oligodeoxyribonucleotide (oligo) was competed by oligos corresponding to an NY-Y/CP1-binding site to a greater extent than by those containing sites for CTF/NF1, C/EPB or CP2. The heat stability, resistance to proteinase K digestion, sensitivity to inhibition of DNA binding by o-phenanthroline, and immunological properties of the liver factor binding to FP160 were very similar to the corresponding properties of NF-Y/CP1. Thus, the proximal ALDH2 promoter was bound by NF-Y/CP1 and this transcription factor may be responsible for the basal expression of the gene observed in most tissues. The NFY-CP1 present in rat liver has similar properties to that previously characterized in M12 B-lymphoma cells and LMTK mouse fibroblasts. http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8964492 http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8964492 http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#_4 http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM http://purl.org/dc/terms/created 2014-07-03T14:33:55.471+02:00 http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAhIymT9roGUwndkBJb760EuLDyCexLMjM_1Hlp_Dz6kM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234