[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8032" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/metastasis" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "kin(p(HGNC:NTRK2)) -> path(SDIS:metastasis)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Several anticancer therapies target, albeit indirectly, the PI3K/ Akt1 axis and cause inhibition of Akt1 phosphorylation and induction of apoptosis. Examples include herceptin, which inhibits ErbB2 in breast cancer cells; cyclooxygenase-2 (COX-2) inhibitors, which inhibit COX-2 and PDK1 in colon and prostate cancer; gefitnib (Iressa), which targets mutant epidermal growth factor receptor in lung cancer cells; and imatinib mesylate (Gleevec, STI- 571), which targets bcr-abl in leukemia. Conversely, inhibition of anoikis, which contributes to metastasis by trkB or TWIST, involves Akt activation. Given that Akt1 binds to Par-4 in diverse cell types, the action of these therapeutic agents may involve regulation of Par-4 function via Akt1." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/16540633" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/16540633" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:32:57.159+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAhHwJ4IkbdGXbJX7qhiesvjKMxPMYhgN38S-730TmTaI#pubinfo" } ]