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[In 10 HBV-monoinfected patients (9 male, mean age 47 �11 [range 27-67] years, 6 hepatitis B e antigen-positive) with virological breakthrough during ADV treatment associated with the mutations rtN236T and/or rtA181T/V, HBV polymerase gene variants were studied during up to 24 months of consecutive monotherapy with TDF by population sequencing, line probe assay and clonal analysis.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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