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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#_3 http://www.w3.org/ns/prov#value We report the crystal structure of calcineurin (CN) in complex with CyPA-CsA at 2.8-A resolution. The CyPA-CsA complex binds to a composite surface formed by the catalytic and regulatory subunits of CN, where the complex of FK506 and its binding protein FKBP also binds. While the majority of the CN residues involved in the binding are common for both immunophilin-immunosuppressant complexes, a significant number of the residues are distinct. Unlike FKBP-FK506, CyPA-CsA interacts with Arg-122 at the active site of CN, implying direct involvement of CyPA-CsA in the regulation of CN catalysis. The simultaneous interaction of CyPA with both the composite surface and the active site of CN suggests that the composite surface may serve as a substrate recognition site responsible for the narrow substrate specificity of CN. The comparison of CyPA-CsA-CN with FKBP-FK506-CN significantly contributes to understanding the molecular basis of regulation of CN activity by the immunophilin-immunosuppressant. http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12218175 http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12218175 http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#_3 http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA http://purl.org/dc/terms/created 2014-07-03T14:31:53.862+02:00 http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAh92N7sdnzmDFIiMJQ1gMPc8YhqYuJbnLfI-BI9MRXIA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234