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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#_4 http://www.w3.org/ns/prov#value MPM cells were responsive to HGF (40 ng/mL) stimulation of c-Met signaling up to 5 hours in a time-dependent fashion (Fig. 2B). Significant induction of tyrosine phosphorylation in c-Met of the autophosphorylation site (pY1230/1234/1235) as well as the regulatory juxtamembrane c-Cbl binding site (pY1003) was evident starting at 15 minutes of HGF stimulation and the phospho-signal declined between 2 and 5 hours. Moreover, phosphorylation of ERK1/2 (pT185/pY187) and AKT (S473) was significantly induced in a differential manner with different cell lines after HGF stimulation (Fig. 2B). http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16397249 http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16397249 http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#_4 http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg http://purl.org/dc/terms/created 2014-07-03T14:32:54.767+02:00 http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAh3P6fe9vj9DRcCl7Rywuvt5tyqBbkhs3-jmQ-4xYHAg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234