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[Recent studies on Abcc6(-/-) mice show that the absence of ABCC6 in the liver is crucial for PXE and confirm the 'metabolic disease hypothesis' for PXE, which states that tissue calcification is due to the absence of a plasma factor secreted from the basolateral hepatocyte membrane.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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