http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#Head http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#provenance http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=8823 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000763 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_1 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/Tetradecanoylphorbol%20acetate http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"Tetradecanoylphorbol acetate") -> r(HGNC:PECAM1) http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_3 http://www.w3.org/ns/prov#value Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is a cell adhesion molecule involved in transendothelial migration and expressed by hemopoietic and endothelial cells. To understand the mechanisms underlying its regulated expression, a genomic clone containing 1555 bp of the 5'-flanking region and the first exon of the human PECAM-1 gene has been isolated. The 5'-flanking region of the PECAM-1 gene lacks a consensus TATA box, but contains consensus motifs for Sp1, EGR1, ets, helix-loop-helix (HLH) box, GATA, AP-2, C/EBP, YY1, CCACC, LyF-1, imperfect octamer, heptamer, high mobility group proteins (HMG) box, and nuclear factor-kappaB, as well as shear stress-, retinoic acid-, glucocorticoid-, and acute phase-responsive elements, and an Alu sequence. Successive 5' to 3' or 3' to 5' deletions revealed tissue-specific promoter activity within the two contiguous 0.22-kb NheI/BglII and 0.44-kb BglII/PstI fragments. The transcriptional activity displayed by the 0.22-kb NheI/BglII fragment was specific for the myeloid lineage, whereas the promoter activity of the 0.44-kb BglII/PstI fragment was apparently restricted to endothelial cells. The transcriptional activity of the 0.22-kb NheI/BglII fragment was confirmed by 5' RACE (rapid amplification of 5' cDNA ends) and S1 nuclease protection experiments that revealed previously unidentified transcription start sites. The 0.22-kb NheI/BglII promoter exhibited PMA inducibility in myeloid cells and contained a PMA-responsive element recognized by Sp1 and EGR-1 transcription factors. Isolation and characterization of the human PECAM-1 promoter represent an initial step in elucidating the controlled expression of the PECAM-1 gene. http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8955189 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8955189 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#_3 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://purl.org/dc/terms/created 2014-07-03T14:33:55.457+02:00 http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAgfmzVSiK3al1NDar_OOknN86ODZpeuXYVb4SHRlcprA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234