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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#_3 http://www.w3.org/ns/prov#value These processes result in acute endothelial dysfunction in diabetic blood vessels that, convincingly, also contributes to the development of diabetic complications. These new findings may explain why classic antioxidants, such as vitamin E, which work by scavenging already-formed toxic oxidation products, have failed to show beneficial effects on diabetic complications and may suggest new and attractive \"causal\" antioxidant therapy. New low-molecular mass compounds that act as SOD or catalase mimetics or L-propionyl-carnitine and lipoic acid, which work as intracellular superoxide scavengers, improving mitochondrial function and reducing DNA damage, may be good candidates for such a strategy, and preliminary studies support this hypothesis. This \"causal\" therapy would also be associated with other promising tools such as LY 333531, PJ34, and FP15, which block the protein kinase beta isoform, poly(ADP-ribose) polymerase, and peroxynitrite, respectively. While waiting for these focused tools, we may have other options: thiazolinediones, statins, ACE inhibitors, and angiotensin 1 inhibitors can reduce intracellular oxidative stress generation, http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12716823 http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12716823 http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#_3 http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA http://purl.org/dc/terms/created 2014-07-03T14:32:01.627+02:00 http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAgOBusjcQa738znPL80heF7gMaNmYF3vDBMEdHm4MApA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234