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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#_4 http://www.w3.org/ns/prov#value . Here we show that mice deficient in E2F1 exhibit enhanced angiogenesis. The proangiogenic phenotype in E2F1 deficiency is the result of overproduction of vascular endothelial growth factor (VEGF) and is prevented by VEGF blockade. Under hypoxic conditions, E2F1 down-regulates the expression of VEGF promoter activity by associating with p53 and specifically down-regulating expression of VEGF but not other hypoxia-inducible genes, suggesting a promoter structure context-dependent regulation mechanism. We found that the minimum VEGF promoter mediating transcriptional repression by E2F1 features an E2F1- binding site with four Sp-1 sites in close proximity. These data disclose an unexpected function of endogenous E2F1: regulation of angiogenic activity via p53-dependent transcriptional control of VEGF expression. http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16835303 http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16835303 http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#_4 http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c http://purl.org/dc/terms/created 2014-07-03T14:30:43.937+02:00 http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAgCP3RS5efOIRTawGEjekjyOuBugI1kKS8shhoUHGA7c http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234