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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#_2 http://www.w3.org/ns/prov#value After the initial adhesion of platelets to the extracellular matrix, the repair process requires a rapid response to autocrine and paracrine mediators, including adenosine diphosphate (ADP), thrombin, epinephrine, and thromboxane A2. These mediators amplify and sustain the initial platelet response (Figure 1Figure 1Agonists, Receptors, and Effector Systems in Platelet Activation.), and they recruit circulating platelets from the flowing blood to form a growing hemostatic plug. Most agonists that activate platelets operate through G-protein?coupled receptors.14 The final pathway for all agonists is the activation of the platelet integrin glycoprotein IIb/IIIa (?IIb?3), the main receptor for adhesion and aggregation.15 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18077812 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18077812 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#_2 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE#pubinfo http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE http://purl.org/dc/terms/created 2014-07-03T14:30:52.391+02:00 http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAgAMRtB9TGSNNwRFgGRb4H81xikoBHLDECcpYjPikkmE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234