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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#_5 http://www.w3.org/ns/prov#value In the present study we show that HRG beta 1 is mitogenic for erbB3-transfected DHFR/G8 cells, an NIH3T3 mouse fibroblast derivative that over-expresses p185erbB2/neu. HRG stimulated the incorporation of [3H]thymidine into the DNA of these cells with an EC50 of 70 +/- 7 pM. HRG was not mitogenic for parental DHFR/G8 cells that do not express the ErbB3 protein. Phosphatidylinositol (PI) 3-kinase, an enzyme believed to be important in cellular growth regulation by growth factors and oncogenes, is predicted to couple to tyrosine-phosphorylated ErbB3. We observed that HRG stimulated the association of PI 3-kinase with both p185erbB2/neu and ErbB3 in transfected DHFR/G8 cells, but not in the parental cell line. http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/7535767 http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/7535767 http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#_5 http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY http://purl.org/dc/terms/created 2014-07-03T14:33:44.556+02:00 http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAg4uTzEG-w5EKWu5CxVWHQvR0LpKyHCqpVSsHoGsVrjY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234