@prefix this: . @prefix rdfs: . @prefix xsd: . @prefix sio: . @prefix ncit: . @prefix lld: . @prefix miriam-gene: . @prefix miriam-pubmed: . @prefix eco: . @prefix wi: . @prefix prov: . @prefix pav: . @prefix prv: . @prefix dcterms: . @prefix np: . @prefix dgn-np: . @prefix dgn-gda: . @prefix dgn-void: . dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_head { this: np:hasAssertion dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_assertion; np:hasProvenance dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_provenance; np:hasPublicationInfo dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_publicationInfo; a np:Nanopublication . dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_assertion a np:Assertion . dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_provenance a np:Provenance . dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_publicationInfo a np:PublicationInfo . } dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_assertion { miriam-gene:57026 a ncit:C16612 . lld:C0596263 a ncit:C7057 . dgn-gda:DGNdcd994dc82523e9a79107b248dc2c24b sio:SIO_000628 miriam-gene:57026, lld:C0596263; a sio:SIO_001121 . } dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_provenance { dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_assertion dcterms:description "[Current data implicating the role of human papillomavirus (HPV) infections in squamous cell carcinogenesis may be summarised as follows: animal models have shown that PVs can induce malignant transformation; HPV involvement in both benign and malignant human squamous cell tumours has been demonstrated by morphological, immunohistochemical and DNA hybridisation techniques; HPV infections in the genital tract are venereally transmitted and are associated with the same risk factors as cervical carcinoma; the natural history of cervical HPV lesions is similar to that of CIN, namely, they have the potential to develop into carcinoma in situ; malignant transformation of PV-induced lesions seems to depend on virus type and the physical state of its DNA, e.g., whether or not it is integrated in the host cell DNA; malignant transformation most probably requires synergistic actions between the PVs and chemical or physical carcinogens, or other infectious agents; genetic disposition (at least in animals) significantly contributes to malignant transformation; immunological defence mechanisms of the host are probably capable of modifying the course of PV infections (efficacy in man remains to be elucidated).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en; wi:evidence dgn-void:source_evidence_literature; sio:SIO_000772 miriam-pubmed:3039265; prov:wasDerivedFrom dgn-void:befree-20140225; prov:wasGeneratedBy eco:ECO_0000203 . dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date . dgn-void:source_evidence_literature a eco:ECO_0000212; rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en; rdfs:label "DisGeNET evidence - LITERATURE"@en . } dgn-np:NP188395.RAg2R7Y1w-PrsgTbZfHvctQ8qJfYOHNtmKomOAQpHdlso130_publicationInfo { this: dcterms:created "2014-10-02T12:33:43+02:00"^^xsd:dateTime; dcterms:rights ; dcterms:rightsHolder dgn-void:IBIGroup; dcterms:subject sio:SIO_000983; prv:usedData dgn-void:disgenetrdf; pav:authoredBy , , , , ; pav:createdBy ; pav:version "v2.1.0.0" . dgn-void:disgenetrdf pav:version "v2.1.0" . }