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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_5 http://www.w3.org/ns/prov#value used siRNAto specifically deplete b-catenin to investigate the potential of accumulated b-catenin to trigger activation of the UPR. Despite treatment with enzastaurin, phosphorylation of eIF2a and induction of CHOP, 2 key markers of the early UPR, were markedly inhibited on depletion of b-catenin (Figure 2D top). Moreover, enzastaurin-induced up-regulation of p21(WAF) was also abrogated on depletion of b-catenin...These findings indicate that enzastaurininduced accumulation of v-catenin activates the PERK-eIF2a-CHOP branch of the UPR and thereby contributes to early growth arrest induced by enzastaurin via p21(WAF)...Similar to enzastaurin, the PKC inhibitor BIM I also induced b-catenin accumulation and triggered activation of the UPR in both MM.1S #basically saying that enzastaurin-induction of UPR is dependent on CTNNB1 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19018094 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19018094 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_5 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA http://purl.org/dc/terms/created 2014-07-03T14:33:29.363+02:00 http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234