@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix do: <http://disease-ontology.org/term/DOID:> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:2514;
    a Protein: .
  
  sub:_2 hasAgent: sub:_3;
    a go:0016301 .
  
  sub:_3 geneProductOf: hgnc:24921;
    a Protein: .
  
  sub:_4 occursIn: do:9538, species:9606;
    rdf:object sub:_2;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:CTNNB1) -> kin(p(HGNC:EIF2AK1))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_6;
    pav:version "20131211" .
  
  sub:_5 prov:value "used siRNAto specifically deplete b-catenin to investigate the potential of accumulated b-catenin to trigger activation of the UPR. Despite treatment with enzastaurin, phosphorylation of eIF2a and induction of CHOP, 2 key markers of the early UPR, were markedly inhibited on depletion of b-catenin (Figure 2D top). Moreover, enzastaurin-induced up-regulation of p21(WAF) was also abrogated on depletion of b-catenin...These findings indicate that enzastaurininduced accumulation of v-catenin activates the PERK-eIF2a-CHOP branch of the UPR and thereby contributes to early growth arrest induced by enzastaurin via p21(WAF)...Similar to enzastaurin, the PKC inhibitor BIM I also induced b-catenin accumulation and triggered activation of the UPR in both MM.1S #basically saying that enzastaurin-induction of UPR is dependent on CTNNB1";
    prov:wasQuotedFrom pubmed:19018094 .
  
  sub:_6 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:19018094;
    prov:wasDerivedFrom beldoc:, sub:_5 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:33:29.363+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}