[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_1", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=2514" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_2", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0016301" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_3" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_3", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=24921" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_4", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://disease-ontology.org/term/DOID:9538" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_2" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "p(HGNC:CTNNB1) -> kin(p(HGNC:EIF2AK1))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_6" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_5", "http://www.w3.org/ns/prov#value" : [ { "@value" : "used siRNAto specifically deplete b-catenin to investigate the potential of accumulated b-catenin to trigger activation of the UPR. Despite treatment with enzastaurin, phosphorylation of eIF2a and induction of CHOP, 2 key markers of the early UPR, were markedly inhibited on depletion of b-catenin (Figure 2D top). Moreover, enzastaurin-induced up-regulation of p21(WAF) was also abrogated on depletion of b-catenin...These findings indicate that enzastaurininduced accumulation of v-catenin activates the PERK-eIF2a-CHOP branch of the UPR and thereby contributes to early growth arrest induced by enzastaurin via p21(WAF)...Similar to enzastaurin, the PKC inhibitor BIM I also induced b-catenin accumulation and triggered activation of the UPR in both MM.1S #basically saying that enzastaurin-induction of UPR is dependent on CTNNB1" } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/19018094" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_6", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/19018094" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#_5" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:33:29.363+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAfzRW4t0h9_t4CNh95EB2MhPYvALsJgV_hOqUpnidchA#pubinfo" } ]