http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#Head http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#provenance http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5986 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5438 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000842 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_2 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_1 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.w3.org/2000/01/rdf-schema#label p(HGNC:IL18) -> p(HGNC:IFNG) http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_4 http://www.w3.org/ns/prov#value All effects of% histamine on cytokine responses were also abolished by the presence of either anti-IL-18 Ab or IL-1beta-converting enzyme/caspase-1 inhibitor, indicating that the histamine action is dependent on mature IL-18 secretion and that IL-18 production is located upstream of the cytokine cascade activated by histamine. Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famotidine in a concentration-dependent manner, but not by H1 and H3 receptor antagonists. The addition of recombinant human IL-18 to the culture concentration-dependently stimulated IL-12 and IFN-gamma production and inhibited the IL-2 and IL-10 production. http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10843724 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10843724 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#_4 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://purl.org/dc/terms/created 2014-07-03T14:31:35.731+02:00 http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAfvBpH3ZOeeZIrIIhPKQmfvjeV-wrvgKzFb77zBJ9Yxc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234