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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#_3 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#_2 http://www.w3.org/ns/prov#value Activation of nuclear CaMKII and MEF2 To test for changes in CaMKII phosphorylation, fibers were stimulated with a 5-s duration 10-Hz train every 50 s for 1 h with or without 5 microM KN-62 in the Ringer's solution and fixed and stained with primary antibody to activated (autophosphorylated; Fig. 3 A, open bars) or total (Fig. 3 A, filled bars) CaMKII. 1 h of 10-Hz train stimulation significantly increased (P less than 0.01) the mean nuclear stain of activated CaMKII compared with unstimulated fibers, and KN-62 (5 microM) blocked the increase in activated CaMKII staining after stimulation (Fig. 3 A). In parallel experiments, in which the fibers were stained with antibody directed against total CaMKII, there was no difference in mean nuclear antibody stain between stimulated and unstimulated fibers (P greater than 0.05; Fig. 3 A). These results are consistent with activation of nuclear CaMKII by fiber electrical stimulation without any appreciable translocation of CaMKII from the cytoplasm to the nucleus. http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15767461 http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15767461 http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#_2 http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc http://purl.org/dc/terms/created 2014-07-03T14:32:41.612+02:00 http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAftS0Ab1kpT6jI4M6IWgDxcFar-TBg_UAEY7K3Wd2Fmc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234