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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAfgx8e3OEwEfZNXth3tsYeIIGGHnun8SpOIGkJ_hBwDQ#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAfgx8e3OEwEfZNXth3tsYeIIGGHnun8SpOIGkJ_hBwDQ#_3 http://www.w3.org/ns/prov#value from full text - It has been reported that cytokine IL-12 may act in synergy with IL-18 to promote the induction of IFN-gamma, leading to severe gut inflammation in mice[39]. The development of Th1 CD4+ T cells in the intestinal mucosa is driven by IL-12, produced from activated macrophages, and IL-18, produced from activated macrophages and colonic epithelial cells. 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