. . . . . . . . . . . . . "p(MGI:Ifng) -> bp(GOBP:\"inflammatory response\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "from full text - It has been reported that cytokine IL-12 may act in synergy with IL-18 to promote the induction of IFN-gamma, leading to severe gut inflammation in mice[39]. The development of Th1 CD4+ T cells in the intestinal mucosa is driven by IL-12, produced from activated macrophages, and IL-18, produced from activated macrophages and colonic epithelial cells. The synergistic effect is mainly caused by mechanisms involving the upregulation of the IL-18 receptor by IL-12[40]." . . "Selventa" . . . . "2014-07-03T14:33:23.769+02:00"^^ . . .