@prefix this: <http://rdf.disgenet.org/nanopublications.trig#NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/eco.owl#> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/2.0/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/nanopublications.trig#> .
@prefix dgn-gda: <http://rdf.disgenet.org/gene-disease-association.ttl#> .
@prefix dgn-void: <http://rdf.disgenet.org/v2.1.0/void.ttl#> .

dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_head {
  this: np:hasAssertion dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_assertion;
    np:hasProvenance dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_provenance;
    np:hasPublicationInfo dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_assertion a np:Assertion .
  
  dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_provenance a np:Provenance .
  
  dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_assertion {
  miriam-gene:1269 a ncit:C16612 .
  
  lld:C2711227 a ncit:C7057 .
  
  dgn-gda:DGN8ce24df60a30c303f973e0dbf483ab2c sio:SIO_000628 miriam-gene:1269, lld:C2711227;
    a sio:SIO_001121 .
}

dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_provenance {
  dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_assertion dcterms:description
      "[In particular, hepatoprotective properties for Cannabinoid Receptor type 2 (CB2) have been shown both through experimental murine models of liver injury and association study between a CB2 functional variant, Q63R, and liver enzymes in Italian obese children with steatosis.Here, in order to clarify the role of CB2 in severity of childhood NAFLD, we have investigated the association of the CB2 Q63R variant, with histological parameters of liver disease severity in 118 Italian children with histologically-proven NAFLD.CB2 Q63R genotype was assigned performing a TaqMan assay and a general linear model analysis was used to evaluate the association between the polymorphism and the histological parameters of liver damage.We have found that whereas CB2 Q63R variant is not associated with steatosis or fibrosis, it is associated with the severity of the inflammation (p = 0.002) and the presence of NASH (p = 0.02).Our findings suggest a critical role for CB2 Q63R variant in modulating hepatic inflammation state in obese children and in the consequent increased predisposition of these patients to liver damage.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:22927922;
    prov:wasDerivedFrom dgn-void:befree-20140225;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20140225 pav:importedOn "2014-02-25"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP278066.RAfL5DPiiF8TZsbAZyc5pNl7GoypHwLYLwmqJMG1Kw8iE130_publicationInfo {
  this: dcterms:created "2014-10-02T12:34:37+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetrdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v2.1.0.0" .
  
  dgn-void:disgenetrdf pav:version "v2.1.0" .
}