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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAf0X7I9Mg9vvVZS7M5nSX3emreqkcq9GQ_H2GP8bXRpk#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAf0X7I9Mg9vvVZS7M5nSX3emreqkcq9GQ_H2GP8bXRpk#_3 http://www.w3.org/ns/prov#value To investigate whether nicotine or NNK could stimulate the Akt pathway in fully transformed lung cancer cells, we used two NSCLC cell lines (H157 and H1703) and one small cell lung cancer (SCLC) cell line (H69) to assess phosphorylation of Akt at S473, which is indicative of Akt activation. Nicotine or NNK rapidly increased Akt activation in all three cell lines. Note: Nicotine: 2- to 3-fold within 15--30 min (Figure 1A). 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