@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAf-P5fR0XR1pB7a1PwQ2Y9dBG9Z8DFik9OOQIa2jkG60> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAf-P5fR0XR1pB7a1PwQ2Y9dBG9Z8DFik9OOQIa2jkG60#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
   sub:_1 geneProductOf: hgnc:11766 ;
    a Protein: .
  sub:_2 geneProductOf: hgnc:6436 ;
    a Protein: .
  sub:_3 occursIn: obo:UBERON_0001264 , species:9606 ;
    rdf:object sub:_2 ;
    rdf:predicate belv:decreases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:assertion rdfs:label "p(HGNC:TGFB1) -| p(HGNC:KRT19)" .
}
sub:provenance {
   beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "TGF-beta1 stimulation of COLO-357, PANC-1, and IMIM-PC1 cells lead to a down-regulation of cytokeratins 8 and 19 mRNA levels in PANC-1 and IMIM-PC1 (responsive cell lines)cells and to a minor extent in COLO-357 cells. The mesenchymal differentiation marker vimentin and collagen1alpha is strongly up-regulated in all responsive cell lines. The TGF-beta1 mediated regulation of differentiation markers occurs in a time-dependent manner. In contrast, TGF-beta1 treatment failed to induce any significant change in the expression pattern of differentiation markers in cell lines with a nonfunctional TGF-beta1 signaling pathway (IMIM-PC2 and CAPAN-1). The TGF-beta1 mediated changes of gene expression were also reproducibly observed on the protein level in all responsive cell lines in multiple experiments; however, down-regulation of epithelial marker proteins was less prominent on the RNA level." ;
    prov:wasQuotedFrom pubmed:11358848 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:11358848 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}
sub:pubinfo {
   this: dct:created "2014-07-03T14:31:41.722+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}