@prefix this: <http://rdf.disgenet.org/resource/nanopub/NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix sio: <http://semanticscience.org/resource/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix lld: <http://linkedlifedata.com/resource/umls/id/> .
@prefix miriam-gene: <http://identifiers.org/ncbigene/> .
@prefix miriam-pubmed: <http://identifiers.org/pubmed/> .
@prefix eco: <http://purl.obolibrary.org/obo/> .
@prefix wi: <http://purl.org/ontology/wi/core#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix pav: <http://purl.org/pav/> .
@prefix prv: <http://purl.org/net/provenance/ns#> .
@prefix dcterms: <http://purl.org/dc/terms/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix dgn-np: <http://rdf.disgenet.org/resource/nanopub/> .
@prefix dgn-gda: <http://rdf.disgenet.org/resource/gda/> .
@prefix dgn-void: <http://rdf.disgenet.org/v3.0.0/void/> .

dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_head {
  this: np:hasAssertion dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_assertion;
    np:hasProvenance dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_provenance;
    np:hasPublicationInfo dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_publicationInfo;
    a np:Nanopublication .
  
  dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_assertion a np:Assertion .
  
  dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_provenance a np:Provenance .
  
  dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_publicationInfo a
      np:PublicationInfo .
}

dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_assertion {
  miriam-gene:7157 a ncit:C16612 .
  
  lld:C0242379 a ncit:C7057 .
  
  dgn-gda:DGNd747fc8f6dc65bec98be6e27be25f230 sio:SIO_000628 miriam-gene:7157, lld:C0242379;
    a sio:SIO_001121 .
}

dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_provenance {
  dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_assertion dcterms:description
      "[This model showed that: (i) the combination of five genetic alterations (CDK4, hTERT, sh-p53, KRAS(V12), and c-MYC) is sufficient for full tumorigenic conversion of HBECs; (ii) genetically identical clones of transformed HBECs exhibit pronounced differences in tumor growth, histology, and differentiation; (iii) HBECs from different individuals vary in their sensitivity to transformation by these oncogenic manipulations; (iv) high levels of KRAS(V12) are required for full malignant transformation of HBECs, however, prior loss of p53 function is required to prevent oncogene-induced senescence; (v) overexpression of c-MYC greatly enhances malignancy but only in the context of sh-p53+KRAS(V12); (vi) growth of parental HBECs in serum-containing medium induces differentiation, whereas growth of oncogenically manipulated HBECs in serum increases in vivo tumorigenicity, decreases tumor latency, produces more undifferentiated tumors, and induces epithelial-to-mesenchymal transition (EMT); (vii) oncogenic transformation of HBECs leads to increased sensitivity to standard chemotherapy doublets; (viii) an mRNA signature derived by comparing tumorigenic versus nontumorigenic clones was predictive of outcome in patients with lung cancer.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en;
    wi:evidence dgn-void:source_evidence_literature;
    sio:SIO_000772 miriam-pubmed:23449933;
    prov:wasDerivedFrom dgn-void:befree-20150227;
    prov:wasGeneratedBy eco:ECO_0000203 .
  
  dgn-void:befree-20150227 pav:importedOn "2015-02-27"^^xsd:date .
  
  dgn-void:source_evidence_literature a eco:ECO_0000212;
    rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en;
    rdfs:label "DisGeNET evidence - LITERATURE"@en .
}

dgn-np:NP752255.RAeq-ik-fm3ASaUaYL0rvsCI73E_Z1yQAmUVo6zPmSQHM130_publicationInfo {
  this: dcterms:created "2015-08-25T14:45:14+02:00"^^xsd:dateTime;
    dcterms:rights <http://opendatacommons.org/licenses/odbl/1.0/>;
    dcterms:rightsHolder dgn-void:IBIGroup;
    dcterms:subject sio:SIO_000983;
    prv:usedData dgn-void:disgenetv3.0rdf;
    pav:authoredBy <http://orcid.org/0000-0001-5999-6269>, <http://orcid.org/0000-0002-7534-7661>,
      <http://orcid.org/0000-0002-9383-528X>, <http://orcid.org/0000-0003-0169-8159>, <http://orcid.org/0000-0003-1244-7654>;
    pav:createdBy <http://orcid.org/0000-0003-0169-8159>;
    pav:version "v3.0.0.0" .
  
  dgn-void:disgenetv3.0rdf pav:version "v3.0.0" .
}