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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#_4 http://www.w3.org/ns/prov#value We therefore investigated whether ceramide-induced expression of Txnip may decrease thioredoxin activity.The expression of thioredoxin remained unchanged (Figure 3A red). Ceramide-up-regulated Txnip mostly colocalized with thioredoxin (Figure 3A yellow).Using an insulin reduction assay, ceramide was found to reduce the thioredoxin activity (Figure S1B). To further verify the reduced thioredoxin activity caused by ceramide-up-regulated Txnip, we used human Txnip siRNA to knock down ceramide-induced Txnip expression in Jurkat T cells (Figure 3B). Results showed that the decreased thioredoxin activity elicited by ceramide was rescued after Txnip siRNA treatment (Figure 3B). http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18270325 http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18270325 http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#_4 http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8 http://purl.org/dc/terms/created 2014-07-03T14:33:17.420+02:00 http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAeZX6BqQi1vHj-emkm8eLQEJjiEd5xLrkTXPSHgehZp8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234