sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_5 ;
    pav:version "20131211" .
  sub:_4 prov:value "We therefore investigated whether ceramide-induced expression of Txnip may decrease thioredoxin activity.The expression of thioredoxin remained unchanged (Figure 3A red). Ceramide-up-regulated Txnip mostly colocalized with thioredoxin (Figure 3A yellow).Using an insulin reduction assay, ceramide was found to reduce the thioredoxin activity (Figure S1B). To further verify the reduced thioredoxin activity caused by ceramide-up-regulated Txnip, we used human Txnip siRNA to knock down ceramide-induced Txnip expression in Jurkat T cells (Figure 3B). Results showed that the decreased thioredoxin activity elicited by ceramide was rescued after Txnip siRNA treatment (Figure 3B). " ;
    prov:wasQuotedFrom pubmed:18270325 .
  sub:_5 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:18270325 ;
    prov:wasDerivedFrom beldoc: , sub:_4 .
}