http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#head http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#assertion http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#provenance http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#publicationInfo http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#assertion http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB00344 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB00344 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:drugbank-id APRD00441 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB00344 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:N06AA11 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:438-60-8 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:8597 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:4805 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:322741 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:C07408 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:0555-0595-02 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA451168 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:4976 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46505128 http://bio2rdf.org/drugbank:DB00344 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Protriptyline http://bio2rdf.org/drugbank:DB00344 http://purl.org/dc/terms/description Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, protriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. In addition, TCAs down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Protriptyline may be used for the treatment of depression. http://bio2rdf.org/drugbank:DB00344 http://purl.org/dc/terms/identifier drugbank:DB00344 http://bio2rdf.org/drugbank:DB00344 http://purl.org/dc/terms/title Protriptyline http://bio2rdf.org/drugbank:DB00344 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB00344 http://www.w3.org/2000/01/rdf-schema#label Protriptyline [drugbank:DB00344] http://bio2rdf.org/drugbank:DB00344 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB00344 http://bio2rdf.org/drugbank:DB00344 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/cdi/protriptyline.html http://bio2rdf.org/drugbank:DB00344 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/viv1617.shtml http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#provenance http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#publicationInfo http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#signature.MCwCFBAH63y01vDD http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#signature.MCwCFBAH63y01vDD http://purl.org/nanopub/x/hasSignature MCwCFBAH63y01vDD5DgFdi0TpDgD7wsjAhRfkmmdMN6Voz2lEUTYsjHWUhvJmg== http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#signature.MCwCFBAH63y01vDD http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://purl.org/dc/terms/created 2018-03-30T11:10:42.883+02:00 http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0#signature.MCwCFBAH63y01vDD http://bio2rdf.org/drugbank:DB00344_nanopub.RAeIBLZ6YBRe_K_BloLkJmCbs4-HTYqKRG1u64id6DZT0 http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234