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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#_5 http://www.w3.org/ns/prov#value Increased integrin ligand binding affinity (activation) is triggered by intracellular signaling events. A Ras-initiated mitogen-activated protein kinase pathway suppresses integrin activation in fibroblasts. We used expression cloning to isolate cDNAs that prevent Ras suppression of integrin activation. Here, we report that PEA-15, a small death effector domain (DED)-containing protein, blocks Ras suppression. PEA-15 does not block the capacity of Ras to activate the ERK mitogen-activated protein kinase pathway. Instead, it inhibits suppression via a pathway blocked by a dominant-negative form of the distinct small GTPase, R-Ras. Heretofore, all known DEDs functioned in the regulation of apoptosis. In contrast, the DED of PEA-15 is essential for its capacity to reverse suppression of integrin activation. Thus, certain DED-containing proteins can regulate integrin activation as opposed to apoptotic protease cascades. http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9852038 http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9852038 http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#_5 http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg#pubinfo http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg http://purl.org/dc/terms/created 2014-07-03T14:34:19.019+02:00 http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAeEN2r_d3BmlBnpbz3dcLqR_eNbqN8CR9YG9-HdhyFWg http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234