@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAe1z9bdSMbDQFBJNddN6_X5o_k3armPMyh1NImbGOViM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAe1z9bdSMbDQFBJNddN6_X5o_k3armPMyh1NImbGOViM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix entrez: <http://www.ncbi.nlm.nih.gov/gene/> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .
sub:Head {
  this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:pubinfo ;
    a np:Nanopublication .
}
sub:assertion {
  sub:_1 geneProductOf: entrez:3630 ;
    a Protein: .
  sub:_2 hasAgent: sub:_3 ;
    a go:0016301 .
  sub:_3 geneProductOf: hgnc:391 ;
    a Protein: .
  sub:_4 rdf:object sub:_2 ;
    rdf:predicate belv:increases ;
    rdf:subject sub:_1 ;
    a rdf:Statement .
  sub:_5 occursIn: obo:CL_0000115 , obo:UBERON_0000947 , species:9606 ;
    rdf:object sub:_4 ;
    rdf:predicate belv:decreases ;
    rdf:subject chebi:44952 ;
    a rdf:Statement .
  sub:assertion rdfs:label "a(CHEBI:\"palmitic acid\") -| (p(EGID:3630) -> kin(p(HGNC:AKT1)))" , "p(EGID:3630) -> kin(p(HGNC:AKT1))" .
}
sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_7 ;
    pav:version "20131211" .
  sub:_6 prov:value "Since insulin activates eNOS through Akt, we then investigated whether FFAs have any effects on basal and insulin-stimulated Akt activation, which was monitored by phosphorylation at Ser473 and Ser308 sites. We observed that while linoleic acid had no effects on Akt phosphorylation at Ser473, palmitic acid inhibited Akt phosphorylation at both Ser473 and Ser308 sites in a dose-dependent fashion (Fig. 2A). Palmitic acid also inhibited insulin-stimulated Akt phosphorylation at Ser473 (Fig. 2B), suggesting that palmitic acid may block upstream signaling. " ;
    prov:wasQuotedFrom pubmed:16873694 .
  sub:_7 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16873694 ;
    prov:wasDerivedFrom beldoc: , sub:_6 .
}
sub:pubinfo {
  this: dct:created "2014-07-03T14:33:02.473+02:00"^^xsd:dateTime ;
    pav:createdBy orcid:0000-0001-6818-334X , orcid:0000-0002-1267-0234 .
}