@prefix this: . @prefix rdfs: . @prefix xsd: . @prefix sio: . @prefix ncit: . @prefix lld: . @prefix miriam-gene: . @prefix miriam-pubmed: . @prefix eco: . @prefix wi: . @prefix prov: . @prefix pav: . @prefix prv: . @prefix dcterms: . @prefix np: . @prefix dgn-np: . @prefix dgn-gda: . @prefix dgn-void: . dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_head { this: np:hasAssertion dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_assertion; np:hasProvenance dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_provenance; np:hasPublicationInfo dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_publicationInfo; a np:Nanopublication . dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_assertion a np:Assertion . dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_provenance a np:Provenance . dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_publicationInfo a np:PublicationInfo . } dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_assertion { miriam-gene:1312 a ncit:C16612 . lld:C0524851 a ncit:C7057 . dgn-gda:DGN27f81893218be25607383e6d5e3cfc7b sio:SIO_000628 miriam-gene:1312, lld:C0524851; a sio:SIO_001121 . } dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_provenance { dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_assertion dcterms:description "[In this review paper, I provide a brief overview of the COMT metabolic system, with particular attentions being paid to the following three areas: (i) the regulation of this catechol-metabolizing system by endogenous regulatory factors (mainly S-adenosyl-L-homocysteine and homocysteine) as well as by exogenous factors such as dietary phytochemicals; (ii) decreased metabolic O-methylation of endogenous catecholamines as an important risk factor for the development of neurodegenerative disorders such as Parkinson's and Alzheimer's diseases in the elderly and also as a risk factor for the development of a variety of cardiovascular diseases; and (iii) the relative importance of the COMT-catalyzed O-methylation metabolism of endogenous catechol estrogens in the causation and prevention of estrogen-induced hormonal cancers.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine."@en; wi:evidence dgn-void:source_evidence_literature; sio:SIO_000772 miriam-pubmed:12083324; prov:wasDerivedFrom dgn-void:befree-2016; prov:wasGeneratedBy eco:ECO_0000203 . dgn-void:befree-2016 pav:importedOn "2016-02-19"^^xsd:date . dgn-void:source_evidence_literature a eco:ECO_0000212; rdfs:comment "Gene-disease associations inferred from text-mining the literature."@en; rdfs:label "DisGeNET evidence - LITERATURE"@en . } dgn-np:NP358773.RAe-GWT2Th25MaLYxXkAQFTHS3JQfuJAA2ANfsjWupwYM130_publicationInfo { this: dcterms:created "2016-05-13T12:44:28+02:00"^^xsd:dateTime; dcterms:rights ; dcterms:rightsHolder dgn-void:IBIGroup; dcterms:subject sio:SIO_000983; prv:usedData dgn-void:disgenetv3.0rdf; pav:authoredBy , , , , ; pav:createdBy ; pav:version "v4.0.0.0" . dgn-void:disgenetv3.0rdf pav:version "v4.0.0" . }