http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#Head http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#provenance http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_2 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=6840 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_3 http://www.selventa.com/vocabulary/translocationFrom http://amigo.geneontology.org/amigo/term/GO:0005634 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_3 http://www.selventa.com/vocabulary/translocationOf http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_4 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_3 http://www.selventa.com/vocabulary/translocationTo http://amigo.geneontology.org/amigo/term/GO:0005737 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=5044 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_3 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_1 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(HGNC:MAP2K1)) -> tloc(p(HGNC:HNRNPK),GOCCID:0005634,GOCCID:0005737) http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_6 http://www.w3.org/ns/prov#value Here we show that cytoplasmic accumulation of hnRNP-K is phosphorylation-dependent. Mitogen-activated protein kinase/extracellular-signal-regulated kinase (MAPK/ERK) efficiently phosphorylates hnRNP-K both in vitro and in vivo at serines 284 and 353. Serum stimulation or constitutive activation of ERK kinase (MEK1) results in phosphorylation and cytoplasmic accumulation of hnRNP-K. Mutation at ERK phosphoacceptor sites in hnRNP-K abolishes the ability to accumulate in the cytoplasm and renders the protein incapable of regulating translation of mRNAs that have a differentiation-control element (DICE) in the 3' untranslated region (UTR). http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11231586 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11231586 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#_6 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://purl.org/dc/terms/created 2014-07-03T14:31:39.959+02:00 http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdrxV0PrWTEiu9e4CHNP_mwd0wiZ4u7aydMr2sj2RwhM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234