. . . . . . . . . . . . . . . . "kin(p(HGNC:IKBKE)) => p(HGNC:IRF3,pmod(P,S,385))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "The signaling cascades from these two receptors join at IKK-like kinase, IKK-i and TBK-1, and these kinases play an important role in phosphorylation and activation of the type-I IFN transcription factor, interferon regulatory factor-3 (IRF-3) ... Qin et al. suggested that IRF-3 is autoinhibited in the resting state by interaction between the N-terminal helix of RD and SRR but that the phosphorylation of Ser385 and/or Ser386 in the 2S site induces destabilization of SRR leading to exposure and phosphorylation of Ser396, Ser398 and other Ser/Thr residues (Ser402, Thr404, Ser405) in the 5ST site that can disrupt the autoinhibitory structure (Qin et al. 2003). " . . "Selventa" . . . . "2014-07-03T14:33:39.893+02:00"^^ . . .