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http://purl.obolibrary.org/obo/BFO_0000066
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p(HGNC:GAB1,pmod(P,Y)) -> (p(HGNC:IL6) -> kin(p(SFAM:"MAPK Erk1/2 Family")))
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p(HGNC:IL6) -> kin(p(SFAM:"MAPK Erk1/2 Family"))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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Both the tyrosine phosphatase SHP-2 and the multisubstrate docking molecule Gab1, which are potential links between IL-6 and the MAPK/PI3K pathways, were constitutively associated with the active EGF receptor. On IL-6 stimulation, SHP-2 and Gab1 were recruited to the gp130 subunit of the IL-6 receptor and tyrosine phosphorylated, allowing downstream signaling to the MAPK and PI3K pathways.
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Selventa
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2014-07-03T14:31:39.804+02:00
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