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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#_2 http://www.w3.org/ns/prov#value However, this detoxification process can be overwhelmed in some circumstances. One such circumstance is the depletion of mitochondrial, reduced glutathione. Normally, glutathione peroxidase plays a key role in H2O2 detoxification, as liver mitochondria do not have catalase. However, glutathione peroxidase needs adequate amounts of reduced glutathione in the mitochondrial matrix to detoxify H2O2. The depletion of mitochondrial glutathione below a critical threshold can impair mitochondrial H2O2 detoxification, which can trigger mitochondrial dysfunction, mitochondrial permeability transition (MPT) and cell death [22]. http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#_2 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18705745 http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#_3 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18705745 http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#_2 http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY http://purl.org/dc/terms/created 2014-07-03T14:30:53.434+02:00 http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdY--luY6vCHAFe08EzKGSrp3Zick81eHjiGsRroBtWY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234