http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#Head http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#provenance http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_2 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0016301 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_2 http://purl.obolibrary.org/obo/RO_0002204 http://resource.belframework.org/belframework/20131211/namespace/selventa-protein-families/MEK1%2F2%20Family http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:109161 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000775 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_3 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/decreases http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_1 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.w3.org/2000/01/rdf-schema#label kin(p(SFAM:"MEK1/2 Family")) -| r(MGI:Grk5) http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_5 http://www.w3.org/ns/prov#value Fig. 6 Model of TLR4 and chemokine receptor crosstalk. MIP-2 binding to CXCR2 induces PMN migration, as well as GRK2 and GRK5 expression, through PI3K-? signaling. Increased GRK2 and GRK5 expression results in chemokine receptor internalization and desensitization, thereby negatively regulating PMN migration. Thus, PI3K-?-activated signaling is postulated to be a feedback mechanism regulating PMN migration. Because persistent infection requires continued PMN infiltration, LPS acting through the TLR4 signaling pathway transcriptionally downregulates expression of GRK2 and GRK5 in response to MIP-2. This decreases chemokine receptor desensitization by preventing CXCR2 internalization and thus augments PMN migration. MEK kinase is involved in mediating the crosstalk between TLR4 and chemokine receptors. Dashed lines indicate inhibitory signals. http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12592402 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12592402 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#_5 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://purl.org/dc/terms/created 2014-07-03T14:31:59.032+02:00 http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdOSUoLisdAchc_Mx8eQ7lsODAZAawRG8cPDovOaPnLc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234