http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#head http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#assertion http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#provenance http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#publicationInfo http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#assertion http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB00540 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB00540 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:drugbank-id APRD00602 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB00540 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:28:16.04.28 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:N06AA10 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:72-69-5 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:7640 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:4384 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:2240789 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-gtp http://bio2rdf.org/gtp:2404 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-iuphar http://bio2rdf.org/iuphar:2404 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:C07274 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:54868-2835-2 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA450657 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:4543 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46507783 http://bio2rdf.org/drugbank:DB00540 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Nortriptyline http://bio2rdf.org/drugbank:DB00540 http://purl.org/dc/terms/description Nortriptyline hydrochloride, the N-demethylated active metabolite of amitriptyline, is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, nortriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, nortriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Secondary amine TCAs, such as nortriptyline, are more potent inhibitors of norepinephrine reuptake than tertiary amine TCAs, such as amitriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Nortriptyline exerts less anticholinergic and sedative side effects compared to the tertiary amine TCAs, amitriptyline and clomipramine. Nortriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use). http://bio2rdf.org/drugbank:DB00540 http://purl.org/dc/terms/identifier drugbank:DB00540 http://bio2rdf.org/drugbank:DB00540 http://purl.org/dc/terms/title Nortriptyline http://bio2rdf.org/drugbank:DB00540 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB00540 http://www.w3.org/2000/01/rdf-schema#label Nortriptyline [drugbank:DB00540] http://bio2rdf.org/drugbank:DB00540 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB00540 http://bio2rdf.org/drugbank:DB00540 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/nortriptyline.html http://bio2rdf.org/drugbank:DB00540 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic/nortrip.htm http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#provenance http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#publicationInfo http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#signature.MCwCFE_gFq5AMOJH http://purl.org/nanopub/x/hasPublicKey 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 http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#signature.MCwCFE_gFq5AMOJH http://purl.org/nanopub/x/hasSignature MCwCFE/gFq5AMOJH0UFelpkgnEvBwgIKAhRdmfhmJ5WfkuDBLXFESgGZtC7pVg== http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#signature.MCwCFE_gFq5AMOJH http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://purl.org/dc/terms/created 2018-03-30T11:11:12.781+02:00 http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE#signature.MCwCFE_gFq5AMOJH http://bio2rdf.org/drugbank:DB00540_nanopub.RAdMK2WpHNLBugDBlU76ZG-VNHn8s3dY2Nz9wDgNalxgE http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234