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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_4 http://www.w3.org/ns/prov#value IGF-I, but not vitamin D3, caused a sevenfold increase in the enzymatic activity of both PI 3-kinase and atypical PKC-zeta. Inhibition of IGF-I-inducible PI 3-kinase with either wortmannin or LY294002 abrogated the IGF-I-induced activation of PKC-zeta and totally blocked the enhancement in macrophage differentiation caused by IGF-I. These data establish that PKC-zeta is a putative downstream target of PI 3-kinase that is activated during IGF-I-promoted macrophage differentiation. http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/9570559 http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/9570559 http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#_4 http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ http://purl.org/dc/terms/created 2014-07-03T14:34:07.657+02:00 http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAdLGEK6h_kmOhDBvmtuSNHlBo6491Cwiy82QdKwFmgwQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234