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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAdCpmxCagiXoOofNlU8qMp0RLrzMFY1uZCFFz_8YtoIU#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAdCpmxCagiXoOofNlU8qMp0RLrzMFY1uZCFFz_8YtoIU#_3 http://www.w3.org/ns/prov#value It remains to be determined what the role of Ser-62 phosphorylation is in promoter selection or whether the phosphorylation is the consequence of targeting MYC to specific DNA sequences. Furthermore MYC mutated at Thr-58 fails to activate the expression of BIM, a proapoptotic BH3-only BCL2 family member, resulting in reduced apoptosis and enhanced tumorigenesis (38). Although MYC stimulates apoptosis by regulating many different genes (39, 40), MYC-stimulated expression of BIM is particularly relevant for repression of tumor development (41). BIM functions as a tumor suppressor, at least in MYC-driven B cell leukemia. 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